It seems clear to me that among the manifold issues that the materialist worldview proposes, the fine-tuning problem is the biggest. What is the fine-tuning argument? According to the Biologos website it "refers to the surprising precision of nature's constants, and the beginning state of the universe. To explain the present state of the universe, even the best scientific theories require that the physical constants of nature and the beginning state of the universe have extremely precise values." See their article on the subject here.
Recently, author and lecturer, Eric Metaxas has been making quite a splash discussing this topic publicly. His piece for the WSJ was their most shared article ever. Here he is making the case on Prager University.
This is basically where things are at. Either this argument is true and there is a God or (as the other side sometimes claims) there are an infinite number of universes and this seemingly perfect one is just the lucky winner in an endless sea of possibility. Ironically, the people who tend to claim that science has (or will have) all the answers are positing an un-testable, un-observable and thus un-scientific theory. Outside of that it has philosophical issues, such as if there are truly an infinite number of universes, then all logical possibilities must occur - including a universe in which God exists and created the entire multiverse (whose existence they claim refutes God).
Watch the video and consider for yourself..